Nefertiti lift guide: Botox for jawline definition and neck rejuvenation

The Nefertiti lift is a botulinum toxin (Botox) injection technique named after the Egyptian queen renowned for her long, defined neck. It targets the platysma muscle — a broad, thin sheet of muscle in the neck and lower face — to release its downward pull on the jawline and neck skin, producing lift and definition without surgery. Here is a complete evidence-based guide.

The anatomy: why the platysma matters for jawline and neck aging

Platysma anatomy

The platysma is a broad, paired muscle originating from the fascia over the chest and shoulder, running superiorly to insert into the:
Inferior border of the mandible (jawline)
Skin and subcutaneous tissue of the lower face and cheek (via fibromuscular connections)
Modiolus and lower lip (in many anatomical variants)

The platysma has a dual function in aging:

Downward traction on the lower face:
As the platysma contracts (or loses elasticity), it pulls the lower face and jowl area downward. The medial edges of the paired platysmal muscles (the platysmal bands) become more prominent with age as the overlying skin loses elasticity and fat volume — producing the vertical cords or "turkey neck" appearance.

Contribution to jowling:
The platysmal insertions along the jawline and lower cheek exert inferior traction on the tissue above — contributing to jowl formation by pulling the cheek fat and skin downward over the mandibular border.

Why relaxing the platysma produces a "lift"

When the platysma is weakened with botulinum toxin:
The downward pull on the jawline and lower face is reduced
The opposing upward-pulling muscles (zygomaticus, masseter, temporalis attachments) relatively predominate → the lower face is "unweighted"
The platysmal bands relax → the vertical neck cords become less prominent
Neck skin appears smoother and the cervicomental angle (the angle between neck and chin) becomes more defined

---

The technique: injection mapping

Levy 2007 — the original description

Levy (2007, Journal of Cosmetic and Laser Therapy) first described the systematic Nefertiti lift injection protocol for jawline and neck rejuvenation using botulinum toxin, naming the technique after the Egyptian queen.

Injection sites

The Nefertiti lift uses injections at two anatomical zones:

Zone 1 — Jawline margin (inferior mandibular border):
Small doses (2–4 units of onabotulinumtoxinA per point) placed every 1–1.5 cm along the inferior border of the mandible — from the chin to the angle of the jaw. These injections weaken the platysmal fibers pulling downward on the jawline and jowl tissue.

Zone 2 — Platysmal bands:
The medial platysmal bands (the visible cords when the patient tenses the neck) are injected in two to three horizontal rows:
Row 1: At the inferior border of the neck (clavicular area)
Row 2: Mid-neck level
Row 3: Just below the mandible

Each platysmal band receives 2–4 units per injection point; spacing 1–1.5 cm along the band length.

Total dose: Typically 40–80 units of onabotulinumtoxinA for a complete Nefertiti lift (jawline + both platysmal bands). Lower doses for conservative initial treatment; full dose for established banding and laxity.

Injection safety considerations

Dysphagia risk: The platysma is in close proximity to the muscles of swallowing (sternocleidomastoid, infrahyoid muscles). Injections too deep or too close to the central neck risk toxin diffusion to swallowing musculature → dysphagia or dysphonia. Experienced injectors maintain superficial placement in the platysma and avoid the midline inferior to the hyoid bone.

Neck weakness: Superficial placement in the platysma produces the cosmetic effect; deep injection risks sternocleidomastoid weakness → neck weakness, difficulty holding the head up.

---

What the Nefertiti lift achieves

Realistic effect size

The Nefertiti lift produces mild-to-moderate improvement that is appropriate for:
Early jowling — the slight fullness below the jawline that has just begun to appear
Mild platysmal banding — visible neck cords that appear with facial expression or with age at rest
Loss of cervicomental angle definition — early "double chin shadow" or loss of jawline crispness
Pre-event jawline sharpening — the Nefertiti lift is popular as a "jawline sharpening" treatment; effects visible at 5–7 days and lasting 3–5 months

What it does not achieve

Significant jowling: When jowl tissue has fully prolapsed below the mandibular border, Botox cannot physically lift the bulk of displaced fat and tissue. Fillers (to restore the mandibular border definition), threads, HIFU, or surgery are required.

Excess neck skin or platysmal laxity: Significant platysmal laxity with excess skin (the classic "turkey wattle") requires surgical platysmaplasty — the surgical technique of tightening the platysmal bands in the midline — not toxin alone.

Submental fat: Platysmal relaxation does not address submental fat accumulation. Kybella, cryolipolysis, or liposuction address the fat component.

---

Comparison: Nefertiti lift vs. other neck rejuvenation options

| Treatment | Mechanism | Best For | Downtime | Durability |
|---|---|---|---|---|
| Nefertiti lift (Botox) | Platysmal relaxation → reduced inferior traction | Early jowling, mild banding, jawline sharpening | None | 3–5 months |
| PDO thread lift | Mechanical lifting via barbed sutures | Moderate jowling and laxity | 2–5 days | 12–18 months |
| HIFU (Ultherapy) | SMAS heating and collagen remodeling | Mild–moderate laxity, SMAS tightening | Minimal | 12–18 months |
| Thermage (monopolar RF) | Volumetric dermal RF heating | Mild laxity, skin quality | None | 12–18 months |
| Kybella + Nefertiti | Fat dissolution + platysmal relaxation | Submental fat + early jowling combination | 1–3 days (Kybella) | Long-lasting (fat) + 3–5 months (Botox) |
| Surgical platysmaplasty | Platysmal band plication in midline | Significant banding and laxity | 2–3 weeks | 7–10+ years |

---

Who is a good candidate

Best candidates:
Patients with early jawline definition loss and mild platysmal banding
Those who already receive Botox for other areas and want jawline maintenance
Patients wanting a non-surgical "jawline sharpening" effect for an event or general maintenance
Those with good skin elasticity — if significant skin laxity is present, adding a complementary treatment (HIFU, filler) produces better results

Not appropriate (or needs additional treatment):
Significant jowling with prolapsed tissue below the mandibular border
Prominent submental fat accumulation (needs fat reduction, not platysmal relaxation)
Severe platysmal banding with excess skin (surgical)
Previous neck surgery — altered anatomy requires experienced assessment

---

Post-treatment and duration

Onset: Botulinum toxin effect begins at 3–5 days; full effect at 10–14 days.

Duration: 3–5 months, similar to standard Botox duration for most facial areas. The neck/jawline area has been observed to last slightly shorter in some patients due to active platysmal use with speaking and swallowing.

Repeat treatment: Every 3–5 months to maintain effect. With consistent treatment over 12–24 months, some patients report extended duration as the platysma partially atrophies.

Post-injection: No specific restrictions beyond standard botulinum toxin aftercare — avoid lying down for 4 hours; avoid vigorous exercise for 24 hours; do not massage the injection sites.

---

Looking for a Nefertiti lift or jawline Botox provider? Browse med spa providers on MedSpot →