PRP therapy for skin: what it actually does and what to expect

PRP — platelet-rich plasma — is one of the most misunderstood treatments in aesthetics. It's simultaneously overhyped ("the vampire facial!") and underdiscussed in terms of what it actually does. Here's a clinically grounded look at what PRP therapy is, when it works, and what to ask before booking.

What PRP is and how it works

PRP is derived from your own blood. The process:

A small blood draw (typically 10–30 mL, similar to routine bloodwork)
The blood is spun in a centrifuge that separates plasma from red blood cells
The plasma — now concentrated with platelets at roughly 4–6x the baseline concentration — is collected
Growth factors released from the concentrated platelets are activated

These growth factors — including platelet-derived growth factor (PDGF), transforming growth factor (TGF-β), and vascular endothelial growth factor (VEGF) — signal the body's repair mechanisms: collagen production, cell proliferation, new blood vessel formation.

The two main delivery methods

Topical PRP after microneedling ("vampire facial"):
The PRP is applied to the skin immediately after a microneedling treatment, when the micro-channels created by the needles allow enhanced penetration. The combination produces a stronger collagen-induction response than either treatment alone.

Injectable PRP (intradermal or subdermal):
PRP is injected directly into the dermis or sub-dermally in areas where tissue quality or volume restoration is the goal — most commonly under-eyes (tear trough), scalp (for hair loss), and joint tissue for non-aesthetic applications.

What PRP actually treats (with evidence)

Strong evidence:
Alopecia (hair loss) — multiple RCTs show significant improvements in hair count and thickness; typically 3 sessions over 3 months for initial results
Androgenetic alopecia — particularly responsive for early-to-moderate stages

Moderate evidence:
Skin texture and fine lines — combined with microneedling; consistent improvement in texture and early aging in controlled studies
Tear trough hollowing — injectable PRP shows improvement in tissue quality and mild volume; weaker than HA filler but uses your own biology

Lower evidence (but clinically used):
Acne scarring — combined with microneedling; some patients respond well, improvement is less predictable than ablative laser
General skin rejuvenation — subjective improvement in radiance and quality commonly reported; difficult to separate from microneedling effect in combined protocols

What PRP will not do

PRP is not a replacement for:
Dermal fillers — PRP injected into hollow areas produces subtle improvement, not the immediate volume correction of HA filler
Laser resurfacing — for significant sun damage or scarring, ablative/fractional laser produces more dramatic and predictable results
Neuromodulators — PRP does not relax muscles or smooth dynamic wrinkles

The patients who are disappointed with PRP are usually patients who expected visible, immediate volume correction or dramatic skin change. PRP requires patience: most collagen response builds over 3–6 months.

Who responds best to PRP

Patients with realistic expectations for gradual improvement
Patients seeking tissue quality and longevity improvements over immediate visible correction
Hair loss patients in early-to-moderate stages of androgenetic alopecia
Patients interested in using their own biology rather than introducing foreign substances

Patients who may not be good candidates: those on blood thinners (affects platelet function), active infections or skin conditions in the treatment area, thrombocytopenia, certain autoimmune conditions.

What a session looks like

For PRP microneedling:
Topical numbing cream applied 30–45 minutes before
Blood draw — small amount, similar to routine labs
Centrifuge run (15–20 minutes)
Microneedling treatment
Activated PRP applied to the skin immediately after — absorbed through the micro-channels
Mild redness for 24–48 hours; sometimes subtle bruising

For injectable PRP:
Blood draw and centrifuge run
Injection with fine needles at target sites — minimal discomfort with topical numbing
Mild swelling and redness at injection sites for 24–72 hours

Sessions required

Hair restoration: typically 3 sessions over 3 months, then 1–2 maintenance sessions per year.

Facial skin: 1–3 sessions spaced 4–6 weeks apart for initial results; annual maintenance thereafter.

What to ask at your consultation

"What centrifuge system do you use and what's the typical platelet concentration achieved?"
"Do you use a kit-based system or process the blood in-house?"
"How many sessions do you recommend for my specific concern?"
"Are you combining PRP with microneedling or using it as a standalone injectable?"

A provider who can explain the centrifuge system and expected platelet concentration is a provider who understands the treatment.

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